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Last update September 2024

Hodgkin vs Non-Hodgkin Lymphoma

What are the key differences between Hodgkin and non-Hodgkin lymphoma in terms of symptoms, treatment, and prognosis?

Answered by

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Lisa Miller, Patient Advocate

Hodgkin and Non-Hodgkin lymphomas are two primary types of lymphoma, a cancer that starts in the lymphatic system.

While they share many similarities in symptoms, their differences in progression, treatment, and survival rates are significant.

Understanding these distinctions is crucial for patients and healthcare providers when determining the best approach to care.

Here's a breakdown of the key differences between these two types of lymphoma.

Both types share common symptoms like:

  • Enlarged lymph nodes
  • Fever, night sweats
  • Weight loss, fatigue
  • Severe itching
 

Unique to Hodgkin: Pain in lymph nodes after drinking alcohol.

Treatment depends on the type, stage, and the patient's health. Specific differences aren't highlighted but are tailored accordingly.

Prognosis:

  • Hodgkin lymphoma: More predictable, with a higher 5-year survival rate (89%).
  • Non-Hodgkin lymphoma: Less predictable, with a 5-year survival rate of 74%, often diagnosed at later stages.
 

Other Differences:

  • Age at Diagnosis: Hodgkin median age is 39; Non-Hodgkin is 67.
  • Prevalence: Hodgkin is rarer, while Non-Hodgkin is more common .
  • Location: Hodgkin typically starts in the neck, chest, or armpits; Non-Hodgkin can start anywhere in the lymph nodes.

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