Evidence Based Data

Insulin Potentiaton Therapy (IPT)

IPT for Cancer

Insulin Potentiation Therapy (IPT) is an integrative cancer therapy that combines elements of conventional cancer protocols together with alternative methods.

The conventional part of the IPT protocol involves low-dose chemotherapy, and the alternative part utilizes insulin to make the chemo’s targeting skills more effective.

This allows the patient to receive a much lower dose of chemo, making the process significantly more comfortable and safe, while also avoiding any serious side effects that would normally accompany chemotherapy usage.

IPT has been studied in patients with prostate cancer, and colorectal cancer with promising results.

Arcadia Insulin Potentiation Therapy (IPT)


How Does IPT Work?


When doctors discovered that sugar was one of the main sources of food for cancer, an idea arose – what would happen to cancer if a patient’s blood sugar levels were lowered? What would that do to the cancer cells?

The insulin aspect of IPT was introduced and is very important for two reasons:

1. When insulin is injected into a patient’s body, it lowers their sugar levels. This makes the cancer cells very hungry, weak and irritated, creating a state called ‘metabolic stress.’ Because the cancer is starving, it is not strong enough to fight the chemotherapy when it enters the body.

2. Cancer cells have more insulin receptors on their surface than any of the other healthy cells in the body. When insulin is injected, it binds onto these receptors – almost as if it’s targeting the cells for the incoming chemotherapy.

When cancer cells are targeted this way, chemotherapy is actually more prone to going after the cancer cells themselves rather than other cells in the body.

The amount of insulin used varies per patient and is calculated based on the patient’s body weight and blood results. The patient is monitored for roughly 30 minutes after receiving the insulin, to ensure that they have entered the state of metabolic stress. At that point, a low dose (between 10-25% of a conventional dose) of chemotherapy is injected into the body.

Because the cancer is in metabolic stress, the chemotherapy gets a bigger bang for its buck out of every dose with very low side effects.


What Are the Side Effects of IPT?


Despite the involvement of chemotherapy, IPT has almost none of the side effects such as nausea, radical hair loss, liver damage, and DNA distortion that one experiences regularly with standard chemotherapy. Reducing the amount of chemotherapy entering the entire body leads to fewer and much less severe side-effects to the chemotherapy.


Additional Benefits of IPT:


  • IPT is believed to help detoxify the body. During the protocol, toxins are flushed into the circulation, enabling them to leave the body, which is why special attention is given to the liver while undergoing IPT.
  • IPT may change the blood chemistry for the better. Dr. Perez Garcia believes that changes that occur in the “biological terrane” of the body after IPT make it less hospitable to future diseases.

Watch this explanation by Dr. Goodyear:

The History of IPT


IPT was developed in the late 1920s by Dr. Perez Garcia, as an alternative to treating syphilis with almost lethal doses of mercury and arsenic. Back then, it was referred to as cellular therapy, and Dr. Garcia first used this method to treat cancer in 1945




  • How does insulin potentiation therapy work?

IPT uses insulin to improve the effectiveness of conventional chemotherapy. When insulin is injected into the cancer patient’s body, it lowers their blood sugar just like it would for a diabetic patient. This puts the cancer cells into metabolic stress, essentially weakening them so that they are unable to fight the chemotherapy when it enters the body. This creates a higher intracellular concentration of chemotherapy medicine, which then leads to increased drug effectiveness. 

  • How long does insulin therapy take to work?

IPT starts with an initial evaluation to determine the correct dosage of both chemotherapy drugs and insulin for the patient. In its early stages, IPT may be administered as often as twice a week. The schedule and duration are then adjusted based on the individual patient’s results.

  • What are the side effects of insulin therapy?

Because IPT is administered in conjunction with traditional chemotherapy, patients can still expect to experience some of chemotherapy’s common side effects such as hair loss, fatigue, frequent bruising and bleeding, vomiting, anemia, and appetite and weight changes. Notably, reducing the amount of chemotherapy entering the entire body leads to fewer and much less severe side effects of the chemotherapy.

Insulin Potentiation Therapy (IPT Therapy) – Alternative Cancer Treatment
Insulin Potentiation Therapy IPT Alternative Cancer Treatment

Insulin Potentiaton Therapy (IPT)- Relevant Research and News

Low-Dose Chemotherapy with Insulin (IPT) in Combination with Hormone Therapy for Treatment of Castration-Resistant Prostate Cancer

Purpose. To evaluate the results and quality of life of patients with resistant of castration-resistant tumors previously treated with Insulin-potentiation therapy (IPT) combined with hormone therapy.

Materials and methods. Sixteen patients with metastasis prostate tumors after bilateral castration, androgenic blockade, and progression of the disease were observed during the study. The patients were divided into two groups: group A consisting of 8 patients treated with low-dose chemotherapy Epirubicin, Vinblastine, and Cyclophosphamide combined with LHRH agonist and group B consisting of another 8 patients treated with low-dose chemotherapy Docetaxel combined with LHRH agonist.

Results. The overall (groups A and B) results concerning PSA after the sixth IPT show partial effect in 8 out of 16 (50%) patients, stabilization in 4 out of 16 (25%), and progression in 4 out of 16 (25%). The median survival for all treated patients is 11,7 months (range 3–30 months). During the treatment no significant side effects were observed, and no lethal cases occurred.

Conclusion. In spite of the small number of the treated patients with castration-resistant prostate tumors, the preliminary results are promising and this gives us hope and expectations for future serious multicenter research over the possibilities for routine implementation of IPTLD.

Insulin potentiation therapy in the treatment of malignant neoplastic diseases: A three year study

Problem Statement: Even after decades of scientific research, the application of chemotherapy in the
management of neoplastic disease still presents numerous difficulties. Significant, amongst potential complications, are numerous toxicity-related side effects and the potential for chemoresistance. Despite the widespread tendency to include a variety of new chemotherapeutics in different combinations, progress in this area has proven slow going and unsatisfactory due to the aforementioned factors.
Approach: Seeking a new approach, we introduced the method of Insulin Potentiation Therapy (IPT) in our practice. The theoretical basis and the gathered experimental data on insulin’s mode of action, as well as its application in practice, show that IPT is a promising method with low toxicity. Moreover, it facilitates a selectively physiological approach to the management of neoplastic disease using chemotherapy.
In this report, we present the results of our three-year experience applying Insulin Potentiation Targeted Therapy Low Dose (IPTLD) in the treatment of 196 patients diagnosed with a variety of neoplastic diseases.
Results: Our results showed that patients tolerated IPTLD without difficulties, without serious side effects. Our laboratory tests demonstrated that the dose-related toxicity of chemotherapeutics could be largely mitigated when applied in conjunction with insulin, at a fractionated dose in accordance with a dose dense regimen. Upon follow-up, eighty-five of 106 patients (80%) with advanced metastatic disease reported a subjectively significant improvement in their quality of life.
Conclusions: Future extended experimental data and clinical trials would contribute to a more complete  understanding of the therapeutic potential of IPTLD

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