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Last update June 2024

Have there been any clinical trials for DMSO?

I recently read about Dimethyl sulfoxide (DMSO) and I'm wondering if there have been any clinical trials for its use. What have these trials investigated, and what were the outcomes?

Answered by

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Lisa Miller - Patient Advocate

Research from 2010 concludes that: “Methyl sulfone may have clinical potential as a non-toxic agent effective against metastatic melanoma.” Additionally, methyl sulfone has promise as a tool to explore the molecular mechanisms of metastatic transformation as well as fundamental processes such as cell migration, contact inhibition, wound healing and cellular senescence.

Another study that was done in 2012 focused on DMSO and lung cancer. Evidence showed that DMSO could help boost a protein called HLJ1, which fights against tumors in lung cancer cells. The study concluded that DMSO might be a useful starting point for creating new drugs to fight cancer.

In 2023, a review of all published research data related to using DMSO concluded,  “DMSO might be implemented as an effective, safe, and inexpensive differentiation-inducing therapeutic agent to enhance the overall efficacy of the established conventional and complementary cancer treatments.” and “Besides the documented robust differentiation-inducing activities, DMSO has also demonstrated several anti-cancer properties that could further benefit cancer patients, including suppressing proliferation and inducing apoptosis.”

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