Ivermectin Use for Cancer

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Ivermectin is an anti-parasite drug that was first discovered in 1970 by Satoshi Omura and William Campbell.

The researchers have found an unusual bacteria that effectively treated a wide range of parasites – a wonder drug for parasitic diseases for veterinary and human use. For this discovery, they won the Nobel prize in 2015.

Ivermectin is not the only anti-parasitic medication being studied to fight cancer. You can also find Mebendazole (human dewormer) and Fenbendazole (traditionally used as a dog dewormer) in this group of studies on human cancer

Ivermectin for Cancer (nih.gov)

Over many recent studies, Ivermectin shows promise as a potential cancer medication. It possesses anti-inflammation, antiviral, and antitumor properties. A 2020 study concluded that Ivermectin has powerful antitumor effects.

That Includes:  

  • Inhibits cancerous cells and metastasis
  • Promotes programmed cancer cell death
  • Inhibit tumor stem cells 
  • Reverse multidrug resistance 
  • Exerts the optimal effect when used in combination with chemotherapy.

 

The role of Ivermectin in various cancers has received some notoriety among scientists for its beneficial effects on cancer patients. Benefits were studied for breast cancer (TNBC), digestive system cancer, ovarian, hematological, brain, melanoma, respiratory system cancer, and others.

 

 

Ivermectin’s uses in colorectal cancer

A study out of Henan University in China evaluated the application of ivermectin on colon cancer proliferation. The results were that Ivermectin inhibited the proliferation of colon cancer cells by arresting the tumor cell cycle. It also changed the structure of the cells, making them weaker while also inducing apoptosis.

 

This video talks about new research into the potential effect of Ivermectin on Colon Cancer cells.

 

 

Ivermectin and Triple-Negative Breast Cancer

A current clinical trial is now done to test Ivermectine benefits for TNBC patients. The assumption is that giving Ivermectin with pembrolizumab may increase the drug’s effect in shrinking tumors. The study is done on patients with triple-negative breast cancer, which has spread to other places in the body (metastatic). 

It may help the body’s immune system attack cancer and interfere with the ability of tumor cells to grow and spread. Ivermectin may help block the formation of growths that may become cancer. 

 

Ivermectin and Ovarian Cancer

Ivermectin has demonstrated a potential supplemental role in the treatment of ovarian cancer. Ivermectin interacts with the newly discovered gene target KPNB1, to have an anti-tumor effect on epithelial ovarian cancer (EOC) cells. In targeting signaling pathways and preventing dependent development of ovarian cancer cells, Ivermectin can therefore increase the chemosensitivity of ovarian cancer, making it more effective. 

Ivermectin and Glioma

The most common primary malignant brain tumor, glioma, is still incurable because there are no proven treatments. Clinical trials however found that Ivermectin can greatly limit colony formation and proliferation in glioblastoma cells. These cells experience apoptosis, or “programmed cell death”.

Medical research also shows that Ivermectin induces cell cycle arrest and cell death in vitro and in vivo, which inhibits the proliferation of glioma cells and may be a promising treatment for the disease.

 

Ivermectin and Digestive System Cancer 

One of the most prevalent malignant tumors in the world is gastric cancer. In vivo and in vitro gastric cancer cell proliferation was greatly reduced by Ivermectin. According to Nambara’s 2017 study, Ivermectin could be used as a YAP1 inhibitor to treat cancer.  YAP1 has an oncogenic function (causes the development of tumors)  in carcinogenesis.

 

Ivermectin and Melanoma

The most prevalent malignant skin tumor and one with a high fatality rate is melanoma. Studies revealed that clinicians who used IVM to treat melanoma cells discovered that it might successfully decrease malignant activity. It’s interesting to note that IVM may also exhibit activity against wild-type melanoma cells, and its administration in combination with other pharmacological treatments may substantially boost anticancer efficacy.

 

Ivermectin and Hematological cancer

Ivermectin significantly killed leukemia cells at low concentrations without damaging healthy hematopoietic cells in an experiment meant to explore possible leukemia treatments. The plasma membrane became hyperpolarized due to IVM, which increased the number of chloride ions entering the cell and caused the generation of reactive oxygen species (ROS). IVM’s ability to treat leukemia more effectively than daunorubicin and cytarabine has also been demonstrated.

 

Ivermectin and Chemotherapy 

Ivermectin has the best results when combined with other chemotherapy medications because it inhibits tumor stem cells, reverses multidrug resistance, and inhibits tumor growth.

Apoptosis is induced by Ivermectin, and autophagy is reciprocally regulated.

 

Ivermectin Side Effects

  • Eye discomfort or redness
  • Swollen eyes & vision issues
  • Skin irritation, itchiness, rash, or acute skin rash;
  • Bewilderment- a shift in your mental state
  • Issues with balance
  • Difficulty walking
  • Fever
  • Enlarged Glands
  • Discomfort in the stomach or joints
  • Swelling in the hands or feet
  • Rapid heartbeat and breathing difficulties
  • A lack of bowel or bladder control
  • Seizure (convulsions)
  • Neck ache
  • A sense of being dizzy and on the verge of passing out.

 

 

 

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