Sodium Bicarbonate and Cancer

Over two decades ago, an oncologist based in Rome named Dr. Tullio Simoncini proposed the idea that cancer is a fungus and that sodium bicarbonate, otherwise known as baking soda (one of the most powerful anti-fungal substances) can effectively treat cancer.

Simoncini presented his idea with supporting documentation to the Italian Department of Health. His theory was ignored, and Dr. Simoncini was scorned as a doctor for having such an abstract idea and using an unproven treatment on his patients.

Dr. Simoncini strongly believed,  and his patients were proof, that sodium bicarbonate treatments worked. With minimal side effects and very low risk, this treatment was quick, effective, and has worked for people with many different types of cancer. Today, Dr. Simoncini continues to advocate for the effectiveness of baking soda cancer treatment with protocols designed for specific types of cancer.


The Idea of Cancer as a Fungus


Almost everyone has a fungus in their body called candida. This fungus is present on the skin, in the mouth, stomach, and vagina and normally doesn’t cause any problems. This is because our immune systems keep candida growth in check, but when the immune system is compromised, or the fungus otherwise gets out of balance, it can proliferate in the body.

candida and cancer

Dr. Simoncini alleges that candida overgrowth can happen in organs and elsewhere throughout the body, and when the immune system attempts to stop it, it actually creates a tumor. But the immune system can’t get rid of the tumor or the original fungus infection. Why?

According to Simoncini, tumors produce lactic acid because they feed on glucose to survive, and lactic acid is a byproduct of consuming this sugar. So the entire tumor is acidic and creates an acidic environment around it, which leads to stagnated blood flow and reduced oxygenation. The lactic acid that tumors produce keep them safe from a normal immune response which would typically kill them because lactic acid suppresses immune cells.

Some tumors can be more acidic than others, and these tumors are often more prone to metastasize in the body—these are what we would call aggressive cancers.

When a biopsy of a tumor is taken, or surgery is done to remove the tumor, the fungus can enter the bloodstream and subsequently proliferate in other parts of the body, which can produce additional cancers or metastasize.

The immune system becomes taxed from attempting to fight the fungal infection, and traditional cancer therapies such as chemotherapy can hinder the immune system even more. Eventually, the fungus manifests all over the body as the tumors grow, and the result is often a terminal diagnosis.


Sodium Bicarb Cancer Treatment


Conventional anti-fungal drugs available today don’t work on candida overgrowth—so why is sodium bicarb cancer treatment any different?

Fungi can quickly adapt to anti-fungal drugs to resist therapy. However, sodium bicarbonate works so quickly that fungi don’t have a chance to adapt and become immune to it. It works rapidly to penetrate and essentially dissolve the tumor.

In 2018, Scientists at Ludwig Cancer Research discovered that when areas of tumors lack oxygen and become acidic, cancer cells go into a dormant state, making them resistant to treatment. They found that this happens because acidity stops a key molecular switch, mTORC1, which usually helps cells grow and divide. Interestingly, they discovered that baking soda can reverse this effect. When given to mice, baking soda neutralized the acidity in tumors, reactivating mTORC1 and potentially making the cancer cells more sensitive to therapy. “The concept is so easy,” Dang says. “It’s not some $100,000 per year drug. It’s literally just baking soda.” The team is now exploring how this discovery could impact cancer immunotherapy and the behavior of dormant cancer cells.

Applying sodium bicarbonate locally—or as close to the tumor as possible—is best. Dr. Simoncini gives examples of the best route of application on his website: oral administration for cancers of the digestive tract, inhalation for cancers that manifest in the upper airways, and enemas for rectal cancer. If these preferred routes aren’t possible, sodium bicarbonate can also be administered through specific arteries or even a catheter in cases such as that of bladder cancer.

Sodium bicarb cancer therapy can also help improve the pH of tumors, as tumors are very acidic, and sodium bicarbonate is very alkaline, which may help “weaken” the tumor and make it more receptive to other therapies. It can also help reduce the ability of the tumor to metastasize.

In fact, baking soda cancer therapy may be integrated with other treatments. In one study (2017), sodium bicarbonate combined with transarterial chemoembolization yielded a 100% objective response rate, a significant improvement from the 63.6% of the controlled group.

In a 2019 study, scientists found that the acidic environment in tumors makes it hard for certain drugs, like doxorubicin, to enter and affect cancer cells. To solve this, they used tiny liposomes filled with sodium bicarbonate (baking soda) to increase the pH level inside tumors. They tested this on breast cancer cells and found that combining doxorubicin with sodium bicarbonate improved the drug’s ability to fight cancer.


Sodium Bicarb: Other Supporting Clinical Research


Research shows that antacids can actually enhance the effects of conventional cancer treatment, which supports the idea that acidic environments can encourage cancer growth. Antacids were found to decrease cancer reoccurrence in patients.

Another fungus called Malassezia has also been linked strongly to cancer growth in pancreatic cancer. The role of cancer as a fungus may also explain why repeated antibiotic therapy may actually increase one’s risk for cancer, as antibiotics can destroy healthy bacteria that can help modulate candida and other fungi overgrowth in the body.

Sodium Bicarbonate - Relevant Research and News

Will cancer cells be defeated by sodium bicarbonate?

Chao et al. reported an improved version of the transarterial chemoembolization (TACE) procedure for large hepatocellular carcinoma (HCC), in which 5% sodium bicarbonate was infused into tumors to supplement chemotherapeutic agents. In a small randomized control trial, TACE combined with bicarbonate yielded a 100% objective response rate (ORR), a significant improvement from the 63.6% ORR in the TACE alone group ().

This optimized procedure is termed targeting-intratumoral-lactic-acidosis TACE (TILA-TACE), as the authors expect sodium bicarbonate to interrupt lactic acidosis of tumors. Previously, in vitro studies from the same group suggested that lactic acidosis could effectively protect cancer cells against glucose starvation or deprivation (). The phenomenon of lactic acidosis is characterized with an increase in acidity (acidosis) and a buildup of lactate (lactosis). By directly injecting sodium bicarbonate into tumors, the TILA-TACE procedure is expected not to change the lactate concentration in the tumor microenvironment, but to increase the pH to ameliorate acidosis. Thus, the procedure should be considered as an interruption for acidosis instead of lactic acidosis. However, the in vitro study suggested that acidosis alone, but not lactosis, significantly prolonged the survival time of cancer cells under glucose deprivation (). Since the acidosis is more critical for the survival of tumor cells, it would not be a surprise to see a dramatic effect on tumor apoptosis by simply modulating the pH of the tumor microenvironment with sodium bicarbonate.

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