Evidence Based Data

Glutothione

Glutathione is a sulfur-containing compound that is an effective natural antioxidant found in the body. Being a natural detoxifier, it is capable of removing free radicals that allow cancer cells to grow in the body. Cancer patients often go through radiation and chemotherapy, which, coupled with stress associated with the disease, lowers the level of glutathione in the body. Therefore there is a need to increase its level in the bodies of such patients. The most effective way to achieve this is via IV’s. It provides a way of supporting the body’s natural defenses.

Mark Hyman, MD: Glutathione: The “mother” of all antioxidants…

Dr. Oz on Glutathione (how it can help Diabetes, cancer, arthritis, aids, autism)
GLUTATHIONE is the most important molecule you need to stay healthy and prevent aging, cancer, heart disease, dementia and more, and necessary to treat everything from autism to Alzheimer’s disease.
Glutathione: “The Mother of All Antioxidants”

Glutothione- Relevant Research and News

Role of Glutathione in Cancer Progression and Chemoresistance

Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are involved in the etiology and progression of many human diseases including cancer. While GSH deficiency, or a decrease in the GSH/glutathione disulphide (GSSG) ratio, leads to an increased susceptibility to oxidative stress implicated in the progression of cancer, elevated GSH levels increase the antioxidant capacity and the resistance to oxidative stress as observed in many cancer cells. The present review highlights the role of GSH and related cytoprotective effects in the susceptibility to carcinogenesis and in the sensitivity of tumors to the cytotoxic effects of anticancer agents.

Glutathione metabolism in cancer progression and treatment resistance

Glutathione (GSH) is the most abundant antioxidant found in living organisms and has multiple functions, most of which maintain cellular redox homeostasis. GSH preserves sufficient levels of cysteine and detoxifies xenobiotics while also conferring therapeutic resistance to cancer cells. However, GSH metabolism plays both beneficial and pathogenic roles in a variety of malignancies. It is crucial to the removal and detoxification of carcinogens, and alterations in this pathway can have a profound effect on cell survival. Excess GSH promotes tumor progression, where elevated levels correlate with increased metastasis. In this review, we discuss recent studies that focus on deciphering the role of GSH in tumor initiation and progression as well as mechanisms underlying how GSH imparts treatment resistance to growing cancers. Targeting GSH synthesis/utilization therefore represents a potential means of rendering tumor cells more susceptible to different treatment options such as chemotherapy and radiotherapy.

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