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Evidence Based Data

Glutothione

Glutathione is a sulfur-containing compound that is an effective natural antioxidant found in the body. 

Being a natural detoxifier, it is capable of removing free radicals and reducing oxidative stress in the body. 

This process is important for preventing damage to cells and DNA. 

Glutathione also plays a central role in the detoxification of drugs, pollutants, and other harmful substances. It helps to bind to toxins and make them more water-soluble, allowing the body to excrete them more easily.

What Decreases Glutathione Levels?

Glutathione is a key factor in age acceleration: as we age, our glutathione levels will naturally reduce. 

Lower glutathione can be depleted even further through stress, lack of sleep, and exposure to toxins. 

Low levels of glutathione have been associated with various health conditions, including chronic diseases such as cardiovascular disease and neurodegenerative disorders. 

On the other hand, infusing patients with the compound has been used in medical settings for various purposes, including the treatment of acetaminophen overdose and certain liver conditions. It is also being investigated for its potential therapeutic effects in conditions such as Parkinson’s disease, HIV/AIDS, and cancer. A recent study also indicated glutathione may be helpful in addressing inflammation associated with COVID-19

 

Glutathione for Cancer Patients

The toxins of radiation and chemotherapy coupled with stress associated with the disease, lower the level of glutathione in the body. 

Infusing cancer patients with doses of glutathione has been shown to enhance immune function and improve the body’s ability to fight cancer as well as protect healthy cells from chemotherapy-induced toxicity.

 

How Can One Boost Their Glutathione? 

Certain sulfur-rich foods can help boost glutathione levels naturally, including cruciferous vegetables like broccoli, Brussels sprouts, cauliflower, kale, watercress, and mustard greens as well as allium vegetables, like garlic, shallots and onions. Milk thistle, flaxseed, seaweed, and whey have also been shown to increase glutathione. 

 

Supplements are another option and include curcumin, selenium vitamin C, and vitamin E. 

 

Glutathione IV 

The most effective way to increase one’s glutathione level is through an IV.  

When the saline solution that contains the glutathione starts to move through the body, cells are hydrating your cells, which dramatically decreases potential dehydration symptoms. 

The body can absorb more than 90% of the glutathione from an IV treatment, a higher level of bioavailability than an oral supplement or diet and exercise. 

The optimal schedule for a glutathione IV is 1-3 times per week for about 4 to 9 weeks. 

 

Side Effects of IV Glutathione

There typically aren’t any serious side effects from a dose of glutathione IV. 

It is widely known to be safe for adults. The only minor side effects have been cramping, bloating, and lower zinc levels in people who used glutathione over long periods. 

Dr. Oz on Glutathione (how it can help Diabetes, cancer, arthritis, aids, autism)
In this video, Dr. Dana Flavin sheds light on one of the most important antioxidants in our bodies: Glutathione. As a patient with cancer, you’ve likely heard about the benefits of antioxidants, but have you ever wondered how they actually work?
Q&A Segment with Dr Lodi: Glutathione and Cancer

Glutothione- Relevant Research and News

Role of Glutathione in Cancer Progression and Chemoresistance

Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are involved in the etiology and progression of many human diseases including cancer. While GSH deficiency, or a decrease in the GSH/glutathione disulphide (GSSG) ratio, leads to an increased susceptibility to oxidative stress implicated in the progression of cancer, elevated GSH levels increase the antioxidant capacity and the resistance to oxidative stress as observed in many cancer cells. The present review highlights the role of GSH and related cytoprotective effects in the susceptibility to carcinogenesis and in the sensitivity of tumors to the cytotoxic effects of anticancer agents.

Glutathione metabolism in cancer progression and treatment resistance

Glutathione (GSH) is the most abundant antioxidant found in living organisms and has multiple functions, most of which maintain cellular redox homeostasis. GSH preserves sufficient levels of cysteine and detoxifies xenobiotics while also conferring therapeutic resistance to cancer cells. However, GSH metabolism plays both beneficial and pathogenic roles in a variety of malignancies. It is crucial to the removal and detoxification of carcinogens, and alterations in this pathway can have a profound effect on cell survival. Excess GSH promotes tumor progression, where elevated levels correlate with increased metastasis. In this review, we discuss recent studies that focus on deciphering the role of GSH in tumor initiation and progression as well as mechanisms underlying how GSH imparts treatment resistance to growing cancers. Targeting GSH synthesis/utilization therefore represents a potential means of rendering tumor cells more susceptible to different treatment options such as chemotherapy and radiotherapy.

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