About Dr. Ralf Kleef Hyperthermia
We are deeply sorry to inform you that Dr. Kleef, 61, has died in December 2021. He had been battling COVID-19 for several weeks.It is a tragedy and a great loss for all who loved and knew him.
Dr. Kleef was a rare and special spirit. He had a beautiful, meaningful mission in his life: to help others heal and recover from their illnesses.
Our team remains committed to keeping Dr. Kleef's legacy work alive. We will continue Dr. Kleef’s integrative therapy approach and offer our patients the opportunity to fight their diseases with Dr. Kleef’s protocol, just like he would.
Our highly qualified and experienced team will ensure that healing and treatments can continue at the same level of quality.
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Dr. Kleef Medical Center - Immunotherapy & Hyperthermia
Dr. Ralf Kleef founded the Institute for Hyperthermia and Immunotherapy in 1998 in Vienna and treated more than 20,000 patients over the last three decades. The clinic has recently expanded to Budapest, Hungary.
Dr. Kleef developed a unique cancer treatment approach based on his wealth of experience and knowledge. Dr. Kleef creates individualized therapy plans specifically for every patient’s needs: after a thorough diagnosis, combining immunotherapy with loco-regional and whole-body hyperthermia, chemotherapy, ozone therapy, mistletoe therapy, high-dose Vitamin C, and FMT method.
During the treatments, Dr. Kleef makes sure that the side effects of immunotherapy (immune-related adverse effects) occur in much lesser degrees of intensity, making it a safe and easily tolerable protocol for patients.
Kleef Medical Center has one of the most modern and effective hyperthermia departments in the world. Numerous scientific publications and case studies show the therapeutic methods and results.
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Cost and Additional Expenses - Dr. Ralf Kleef Hyperthermia
4-5 weeks of treatment including Hyperthermia + Immunotherapy is approximately 50,000 Euros. (The cost may vary based on the specific treatments needed as well as the treatment length.)
The price does not include:
Accommodation. Patients usually stay in apartments on a monthly basis. We will provide an accommodation list on request.
* Dr. Kleef Immunotherapy and Integrative Oncology is a private-billing outpatient clinic. We will provide all the information needed so you can submit paid bills to your health insurance.
Available Treatments at Dr. Ralf Kleef Hyperthermia
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- Cardiology evaluation including echocardiogram, echocardiography, and stress test
- Checkpoint inhibitor therapy combining ipilimumab and nivolumab
- Fever titrated IL-2 therapy with monitoring control
- Biological cancer therapy
- Whole-body hyperthermia
- Loco-regional Hyperthermia
- Metronomic thermo-chemotherapy
- Ozone therapy
- Mistletoe Therapy
- High-dose Vitamin C therapy
- Vitamin D
- Massage
- Psychologic and Body Talk Consultation
- Fecal Matter Transplant
Special testings and diagnostics:
- LABD - comprehensive bloodwork
- Mistletoe sensitivity test
- CTC/TCA - analysis of the circulating tumor cells and tumor chemosensitivity test assay
- Molecular biology profiling
- Radiology assessment (CT, MRI, ultrasound)
- Cardiology evaluation including echocardiogram, echocardiography, and stress test
Head Doctor
Dr. Ralf Kleef, MD
Dr. Ralf Kleef is both an MD and ND who received his state examination in medicine at the University of Witten-Herdecke, Germany in 1991.
With his training in immunology at Memorial Sloan Kettering Cancer Centre in NYC and later at the NIH, Office of Alternative Medicine (OAM), in 1996 he found his passion: treating cancer through immunotherapy in the footsteps of the father of cancer immunotherapy, William B. Coley.
Conditions Treated
- Cancer
- Allergies
- Inflammatory diseases
- Bronchitis
- Inflammatory bowel disease (ulcerative colitis and Crohn's disease)
- Cystitis
- Prostatitis
- Rheumatic Diseases
- Arthritis
- Back pain
- Cervical spine
- Chronic infections
- Insomnia
- High blood pressure
- Pain Management
- Tinnitus
- Hepatitis C
- Psoriasis
- Lyme disease
Contact Dr. Ralf Kleef Hyperthermia
Video
General Information
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Addressbudapest
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Price Range$$
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Spoken LanguageEnglish, German
Google Reviews
Colleen Williams
00:55 12 Jan 22
Was very disappointed to have to go back to conventional oncology only after 6 months as treatment only worked partially and I could not afford to travel back again overseas. I only really had enough funds to try it only once ( after fundraising) and only did it because I was was given 100 percent good prognosis by Dr Kleef himself but in hindsight should have been told clearly by the team that this is not a one time treatment and that you are expected to come back every 3, 6 months for at least couple of years. The costs of Immunotherapy were high even locally and also started to fail as well within 6 months. I was asked to provide a fresh tumour sample for the DNA analysis report and in hindsight it really did not add value as it did not change or customise the standard treatment offered and it did a lot of damage to my breast as I had it core biopsied while in surgery to insert the port. I did go there with a locally advanced breast tumour hoping to avoid surgery and complete removal of lymph nodes but in hindsight would suggest to others to only use immunotherapy as an alternative to chemo / radiation after surgery. It does not work for all types of cancer, and in particular an ER PR type of breast cancer. The staff were caring enough while I was there but I felt abandoned with a lack of care and follow up advice after the cancer returned with a vengeance and started to spread. Taking an integrative approach now and checking out Jane McClelland’s book called “How to starve cancer and kill it with ferroptosis” to work alongside chemo for a better long term result.PS My sincere condolences to the Kleef family at the recent passing of Dr Kleef. He was a well respected integrative doctor who thought outside the box and they are hard to come by. I deeply respect that he helped many even though he wasn’t able to help me personally.
Jonathan Uebelhack
18:00 23 Oct 21
The Merchant's guild sends its regards.
Colleen Williams
23:49 18 May 21
Was very disappointed to have to go back to conventional oncology only after 6 months as treatment only worked partially and I could not afford to travel back again overseas. I only really had enough funds to try it only once ( after fundraising) and only did it because I was was given 100 percent good prognosis by Dr Kleef himself but in hindsight should have been told clearly by the team that this is not a one time treatment and that you are expected to come back every 3, 6 months for at least couple of years. The costs of Immunotherapy were high even locally and also started to fail as well within 6 months. I was asked to provide a fresh tumour sample for the DNA analysis report and in hindsight it really did not add value as it did not change or customise the standard treatment offered and it did a lot of damage to my breast as I had it core biopsied while in surgery to insert the port. I did go there with a locally advanced breast tumour hoping to avoid surgery and complete removal of lymph nodes but in hindsight would suggest to others to only use immunotherapy as an alternative to chemo / radiation after surgery. It does not work for all types of cancer, and in particular an ER PR type of breast cancer. The staff were caring enough while I was there but I felt abandoned with a lack of care and follow up advice after the cancer returned with a vengeance and started to spread.
Colleen Williams
23:24 18 May 21
Was very disappointed to have to go back to conventional oncology only after 6 months as treatment only worked partially and I could not afford to travel back again overseas. I only really had enough funds to try it only once ( after fundraising) and only did it because I was was given 100 percent good prognosis by Dr Kleef himself but in hindsight should have been told clearly by the team that this is not a one time treatment and that you are expected to come back every 3, 6 months for at least couple of years. The costs of Immunotherapy were high even locally and also started to fail as well within 6 months. I did go there with a locally advanced breast tumour hoping to avoid surgery and complete removal of lymph nodes but in hindsight would suggest to others to only use immunotherapy as a alternative to chemo / radiation after surgery. It does not work for all types of cancer, and in particular an ER PR type of breast cancer. The staff were caring enough while I was there but I felt abandoned with a lack of care and follow up advice after the cancer returned with a vengeance and started to spread.
Julie Lizak
05:51 10 Mar 20
This guy is a complete fraud! Do not set foot in his practice. We brought my Mom from the US, he left for two weeks on vacation to come back and give her “treatment.” A nice man working with him sent us straight to the hospital where they had to help her get to a state where she was cleared to be flown on a private plane with a medical team to arrive home and die days later. Thanks for nothing! Honesty is always the best policy, don’t bring in a new patient who is beyond help. We were beyond devastated and left with nothing but a huge hole in our bank account!!! This happened two years ago. I’m finally ready to fight back.
Biserka Kljaic
17:18 01 Mar 20
Innovative and individual approach, full commitment to patients, positive and encouraging atmosphere.
Andrew James
18:40 26 Feb 20
In 2015 I was diagnosed with stage 4 melanoma and treated with a variety of immunotherapies by Dr. Kleef and his team. It was a comfort to be in the hands of a doctor who recognises that healing takes place in different dimensions: from the physical to the spiritual -- and who tailors treatments to the individual, exercising caution with respect to industry standards. I remember it as a happy time, in an atmosphere of family and within a year I was fully cured. I am forever grateful!
Michael Kutalek
09:42 19 Feb 20
What a remission!In 2012, I was unexpectedly diagnosed with vocal cord cancer. The growth could be removed by laser surgery, but it came back again and again in the following years. In total I had 10 such surgerys within 5 years.In the summer of 2017, the tumor in the larynx started to grow strongly and I slowly began to suffocate. In conventional medicine, extremely hard radiation therapy accompanied by 2-3 rounds of chemotherapy where recommended. Since severe life-long consequential damage is to be expected after this treatment, I was alternatively suggested to remove the larynx. This would have caused the complete loss of my voice.For me personally, neither was an option!In the meantime, I did my research about additional treatment options and I knew that I wanted to go in this direction. My my medical and integrative Doctor, as some of my friends recommended Dr. Ralf Kleef.Right at my first visit I had the strong feeling that I was in the right place.Dr. Kleef startet his treatment with an individualized combination of fever therapy, hyperthermia and checkpoint inhibitors.
After just a few week this impressive process began where my immune system started to fight the tumor in my larynx. At first the tumor enlarged a little bit, but then slowly shrinked. It was a painful process, but it worked perfectly. The tumor disappeared.I still have my larynx today and can speak practically normal.I am very grateful to Dr. Kleef and his team! I am healthy! :D------------------Eine besondere Remission2012 erhielt ich völlig unerwartet die Diagnose Stimmband Karzinom. Die Wucherung konnte zwar mit dem Laser abgetragen werden, allerdings kam sie in den folgenden Jahren immer wieder zurück. In Summe hatte ich 10 solcher Operationen. Im Sommer 2017 begann der Tumor im Kehlkopf stark zu wachsen und ich drohte langsam zu ersticken.Schulmedizinisch wurde damals eine extrem harte Strahlentherapie begleitet von 2-3 Runden Chemotherapie empfohlen. Da nach dieser Behandlung mit schweren lebenslangen Folgeschäden zu rechnen ist, hat man mir alternativ die Entfernung des Kehlkopfes mit völligen Verlust der Stimme vorgeschlagen. Beides war für mich persönlich keine Option. Mittlerweile hatte ich mich eingehend über zusätzliche Behandlungsmöglichkeiten informiert, und ich wusste dass ich in diese Richtung gehen will.Von meinem ganzheitlichen Arzt und auch aus meinem Bekanntenkreis wurde mir Dr. Ralf Kleef empfohlen. Schon bei meinem ersten Besuch hatte ich das starke Gefühl an der richtigen Stelle zu sein. Dr. Kleef verordnete mir eine individualisierte Kombination aus Fiebertherapie, Hyperthermie und Checkpoint-Inhibitoren. Nach nur ein paar Wochen begann dieser beeindruckende Prozess, als das Immunsystem den Tumor in meinem Kehlkopf zu bekämpfen begann. Zuerst vergrößerte sich das Geschwulst noch etwas, um dann langsam zu verschwinden. Es war ein schmerzhafter Prozess, aber es wirkte vollkommen. Der Tumor verschwand. Ich besitze heute meinen Kehlkopf noch und kann praktisch normal sprechen.Ich bin Dr. Kleef und seinem Team sehr dankbar! Ich bin gesund!
David Ashville
22:47 18 Feb 20
Dr. Kleef is one of a kind. After my wife was diagnosed with stage IV breast cancer, we tried many treatments, both conventional and integrative around the world. Some worked for a little bit, but things always progressed and worse than before. We did a lot of research and Dr. Kleef was recommended by several long term stage IV survivors we had gotten in touch with and some of the best integrative oncologists in the US. The results have been astonishing. Within three months tumor markers and all blood work were totally in normal range and the tumors are disappearing completely. My wife still has her hair and feels great, even though the treatment is intense at the time. The treatment is far less toxic, much more individualized and creative than anything else out there that we have come across and is an actual chance at a cure or long-term remission for advanced cancers. The treatment is designed to garner the immune system to defeat the cancer, and if it works, it has dramatic results. We met people in his office who had been told they had 3 months to live from their conventional oncologists that were coming back for maintenance treatments years and years later. We go back occasionally for maintenance as well but things are looking very good. The care there is first class and the staff is unbelievable, including the other doctors at the clinic, especially Dr. Robert. They are extremely careful and detail oriented. We have been at this for years now and no facility can compare to this. We are beyond grateful for him, his staff and his clinic.
Michael Kutalek
10:38 10 Feb 20
What a remission!
In 2012, I was unexpectedly diagnosed with vocal cord cancer. The growth could be removed by laser surgery, but it came back again and again in the following years. In total I had 10 such surgerys within 5 years.In the summer of 2017, the tumor in the larynx started to grow strongly and I slowly began to suffocate. In conventional medicine, extremely hard radiation therapy accompanied by 2-3 rounds of chemotherapy where recommended. Since severe life-long consequential damage is to be expected after this treatment, I was alternatively suggested to remove the larynx. This would have caused the complete loss of my voice.
For me personally, neither was an option!In the meantime, I did my research about additional treatment options and I knew that I wanted to go in this direction. My my medical and integrative Doctor, as some of my friends recommended Dr. Ralf Kleef.
Right at my first visit I had the strong feeling that I was in the right place.Dr. Kleef startet his treatment with an individualized combination of fever therapy, hyperthermia and checkpoint inhibitors.
After just a few week this impressive process began where my immune system started to fight the tumor in my larynx. At first the tumor enlarged a little bit, but then slowly shrinked. It was a painful process, but it worked perfectly. The tumor disappeared.I still have my larynx today and can speak practically normal.
I am very grateful to Dr. Kleef and his team! I am healthy! :D
Erzsébet H.
14:33 26 Jan 20
Kleef Professzor kezelési módszerére többszöri operációkat, sugár- és kemoterápiás kezeléseket követően találtunk rá. Az ő komplex, egyedülálló, személyre szabott kezelésének köszönhetően tumormentes vagyok, jól érzem magam és teljes életet élhetek. A klinika jól felszerelt, a személyzet figyelmes, jól képzett. Csak ajánlani tudom a Kleef Klinikát, ahol a szakmai professzionalizmus mellett a gyógyuláshoz hozzájárul a bátorító, jókedvű, szeretetteljes légkör is. Köszönöm nekik mindezt és sok sikert kívánok a munkájukhoz!
Erzsébet Szőke
13:52 26 Jan 20
Jeffrey H
05:04 10 Jan 20
As a physiologist, I was able to research and compare cancer treatments from clinics all over the world. In my opinion, this is the best choice for treatment there is. They have some amazing cures to their credit including a stage 4 pancreatic. They have all the standard treatments found in all good cancer clinics but their most effective treatments are only available here.Dr. Kleef (a great guy) is a titan among oncologists and has a very professional, friendly staff. They are very cautious during treatment to ensure patient safety. It’s not cheap, so be sure to get an estimate of your costs beforehand. Nice people who will do everything they can to cure you.
Tino Seidl
20:37 06 Oct 19
Valerie Reinsperger
16:05 06 Sep 18
R C
21:17 09 Jun 18
Alles Bestens !
Josef Sterling
11:10 24 Feb 17
Walter Smith
19:16 22 Feb 15
The system of Mr. Kleef is very simple, initially everything looks good and also affordable and then once you send your tumor for therapy you are confronted with additional costs by other doctors in his network you didn´t expect. This also not happend to myself but to other patients I got to know in the waiting room. Kleef is good for a second opinion but be careful if you start your therapy there. Ask for a written therapy plan and the total costs of the whole therapy! But not only his costs but also additional costs for surgeries, leucopheresis, storemytumor, etc.. Don´t start your therapy without this costs in writtten. Otherwise you will end up with 3x the costs.
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